D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy
Identifieur interne : 000310 ( France/Analysis ); précédent : 000309; suivant : 000311D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy
Auteurs : Laurent Pierot [France] ; Claire Desnos [France] ; Jerome Blin [France] ; Rita Raisman [France] ; Daniel Scherman [France] ; France Javoy-Agid [France] ; Merle Ruberg [France] ; Yves Agid [France]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1988.
Abstract
The densities of D1- and D2-type dopamine receptors were measured with [3H]SCH23390 and [3H]spiperone, in the caudate nucleus and putamen of a large series of patients with Parkinson's disease or progressive supranuclear palsy, in relation to markers of dopaminergic and cholinergic innervation of the striatum ([3H]dihydrotetrabenazine binding and choline acetyltransferase activity). Correlations were sought between these parameters and clinical characteristics of the patients (abnormal involuntary movements, dementia, confusional syndrome or treatment).In Parkinson's disease, the densities of both types of receptors were unchanged, whereas in PSP, the density of D2, but not D1-type dopamine receptors, was decreased in the caudate nucleus and the putamen. No correlations between the biochemical and clinical data were found.
Url:
DOI: 10.1016/0022-510X(88)90106-2
Affiliations:
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Agid, Laboratoire de Médecine Expérimentale, INSERM U. 289, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation><affiliation wicri:level="0"><country wicri:rule="zip">France</country><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">86</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="291">291</biblScope><biblScope unit="page" to="306">306</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">FB890763DD020CDFE4B4FC9F1CFEEE904A0C53E3</idno><idno type="DOI">10.1016/0022-510X(88)90106-2</idno><idno type="PII">0022-510X(88)90106-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The densities of D1- and D2-type dopamine receptors were measured with [3H]SCH23390 and [3H]spiperone, in the caudate nucleus and putamen of a large series of patients with Parkinson's disease or progressive supranuclear palsy, in relation to markers of dopaminergic and cholinergic innervation of the striatum ([3H]dihydrotetrabenazine binding and choline acetyltransferase activity). Correlations were sought between these parameters and clinical characteristics of the patients (abnormal involuntary movements, dementia, confusional syndrome or treatment).In Parkinson's disease, the densities of both types of receptors were unchanged, whereas in PSP, the density of D2, but not D1-type dopamine receptors, was decreased in the caudate nucleus and the putamen. No correlations between the biochemical and clinical data were found.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Pierot, Laurent" sort="Pierot, Laurent" uniqKey="Pierot L" first="Laurent" last="Pierot">Laurent Pierot</name></noRegion><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Blin, Jerome" sort="Blin, Jerome" uniqKey="Blin J" first="Jerome" last="Blin">Jerome Blin</name><name sortKey="Desnos, Claire" sort="Desnos, Claire" uniqKey="Desnos C" first="Claire" last="Desnos">Claire Desnos</name><name sortKey="Javoy Agid, France" sort="Javoy Agid, France" uniqKey="Javoy Agid F" first="France" last="Javoy-Agid">France Javoy-Agid</name><name sortKey="Raisman, Rita" sort="Raisman, Rita" uniqKey="Raisman R" first="Rita" last="Raisman">Rita Raisman</name><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><name sortKey="Scherman, Daniel" sort="Scherman, Daniel" uniqKey="Scherman D" first="Daniel" last="Scherman">Daniel Scherman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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